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Article

Adult satellite cells and embryonic muscle progenitors have distinct genetic requirements.

Nature - 30 Jul 2009

Lepper Christoph, Conway Simon J, Fan Chen-Ming

Abstract excerpt

Myogenic potential, survival and expansion of mammalian muscle progenitors depend on the myogenic determinants Pax3 and Pax7 embryonically, and Pax7 alone perinatally. Several in vitro studies support the critical role of Pax7 in these functions of adult muscle stem cells (satellite cells), but a formal demonstration has been lacking in vivo. Here we show, through the application of inducible Cre/loxP lineage...

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Identifiers

PMID: 19554048
DOI: 10.1038/nature08209
PMCID: PMC2767162

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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