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Article

Targeted mutation of mouse skeletal muscle sodium channel produces myotonia and potassium-sensitive weakness.

The Journal of clinical investigation - 1 Apr 2008

Hayward Lawrence J, Kim Joanna S, Lee Ming-Yang, Zhou Hongru, Kim Ji W, Misra Kumudini, Salajegheh Mohammad, Wu Fen-fen, Matsuda Chie, Reid Valerie, Cros Didier, Hoffman Eric P, Renaud Jean-Marc, Cannon Stephen C, Brown Robert H

Abstract excerpt

Hyperkalemic periodic paralysis (HyperKPP) produces myotonia and attacks of muscle weakness triggered by rest after exercise or by K+ ingestion. We introduced a missense substitution corresponding to a human familial HyperKPP mutation (Met1592Val) into the mouse gene encoding the skeletal muscle...

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Identifiers

PMID: 18317596
DOI: 10.1172/JCI32638
PMCID: PMC2260907

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18317596-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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