Article
A1 adenosine receptors mediate hypoxia-induced ventriculomegaly.
Proceedings of the National Academy of Sciences of the United States of America - 30 Sept 2003
Turner Christopher P, Seli Meltem, Ment Laura, Stewart William, Yan Henglin, Johansson Bjorn, Fredholm Bertil B, Blackburn Michael, Rivkees Scott A
Abstract excerpt
Periventricular leukomalacia is characterized by a reduction in brain matter and secondary ventriculomegaly and is a major cause of developmental delay and cerebral palsy in prematurely born infants. Currently, our understanding of the pathogenesis of this condition is limited. In animal models, features of periventricular leukomalacia can be induced by hypoxia and activation of A1 adenosine receptors (A1ARs)....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.