Article
ETS1 variants confer susceptibility to ankylosing spondylitis in Han Chinese.
Arthritis research & therapy - 4 Apr 2014
Shan Shan, Dang Jie, Li Jiangxia, Yang Ze, Zhao Hailing, Xin Qian, Ma Xiaochun, Liu Yongchao, Bian Xianli, Gong Yaoqin, Liu Qiji
Abstract excerpt
INTRODUCTION: ETS1 is a negative regulator of the Th17 differentiation gene and plays a central role in the pathogenesis of autoimmune diseases. We aimed to investigate whether polymorphisms in ETS1 confer susceptibility to ankylosing spondylitis (AS) in Han Chinese. METHODS: We selected seven single nucleotide polymorphisms (SNPs) within ETS1 based on HapMap data and previous genome-wide association study....
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