Investigating the molecular basis of major depressive disorder etiology: a functional convergent genetic approach.

doi:10.1196/annals.1410.018

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Article

Investigating the molecular basis of major depressive disorder etiology: a functional convergent genetic approach.

Annals of the New York Academy of Sciences - 1 Dec 2008

Jabbi Mbemba, Korf Jaap, Ormel Johan, Kema Ido P, den Boer Johan A

Abstract excerpt

Genes play a major role in behavioral adaptation to challenging environmental stimuli, but the complexity of their contribution remains unclear. There is growing evidence linking disease phenotypes with genes on the one hand, and the genesis of stress-related disorders like major depression, as a result of exposure to stressful environmental pathogens on the other. Here we illustrate the convergent role of...

Topics

Biogenic Monoamines
Biomarkers
Brain
Depressive Disorder, Major
Environment
Genetic Predisposition to Disease
Glucocorticoids
Humans
Phenotype
Polymorphism, Genetic
Sex Characteristics
Stress, Psychological

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Identifiers

PMID: 19120090
DOI: 10.1196/annals.1410.018
PMCID: PMC2614701

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