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Article

Microenvironmental Regulation of Glioblastoma Radioresponse

29 Oct 2010

Abstract excerpt

PURPOSE: Brain tumor xenografts initiated from human glioblastoma (GBM) stem-like cells (TSC) simulate the biological characteristics of GBMs in situ. Therefore, to determine whether the brain microenvironment affects the intrinsic radiosensitivity of GBM cells, we compared the radioresponse of GBM TSCs grown in vitro and as brain tumor xenografts. EXPERIMENTAL DESIGN: As indicators of DNA double-strand breaks...

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PMID: 21037023
DOI: 10.1158/1078-0432.ccr-10-2435

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