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Article

Colorectal cancer risk and patients' survival: influence of polymorphisms in genes somatically mutated in colorectal tumors.

Cancer causes & control : CCC - 1 Jun 2014

Huhn Stefanie, Bevier Melanie, Pardini Barbara, Naccarati Alessio, Vodickova Ludmila, Novotny Jan, Vodicka Pavel, Hemminki Kari, Försti Asta

Abstract excerpt

PURPOSE: The first two studies aiming for the high-throughput identification of the somatic mutation spectrum of colorectal cancer (CRC) tumors were published in 2006 and 2007. Using exome sequencing, they described 69 and 140 candidate cancer genes (CAN genes), respectively. We hypothesized that germline variants in these genes may influence CRC risk, similar to APC, which is causing CRC through germline and...

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Source

Identifiers

PMID: 24706189
DOI: 10.1007/s10552-014-0379-1

Genes

APC
EPHB6
TRPV6
ABCA1
ADAMTSL3
ELAC1
EPHA3
ERCC6
KRAS
OBSCN
PKHD1
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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