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Article

Recombinant influenza H1, H5 and H9 hemagglutinins containing replaced H3 hemagglutinin transmembrane domain showed enhanced heterosubtypic protection in mice.

Vaccine - 23 May 2014

Liu Qiliang, Liu Kang, Xue Chunyi, Zhou Jianqiang, Li Xiaoming, Luo Dongyu, Zheng Jing, Xu Shun, Liu George Dacai, Cao Yongchang

Abstract excerpt

Influenza A viruses cause annual epidemics and irregular pandemics. A vaccine with heterosubtypic protection (hetero-protection) has been needed. In the present study, various influenza H1, H3, H5, and H9 hemagglutinin (HA) proteins were expressed in insect cells, and then mice were subcutaneously immunized with the expressed HA proteins, and challenged by influenza A viruses (A/Puerto Rico/8/1934 (H1N1) or...

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Identifiers

PMID: 24704333
DOI: 10.1016/j.vaccine.2014.03.058
PMCID: PMC7115591

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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