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Construction of naïve camelids VHH repertoire in phage display-based library

20 Mar 2014

Abstract excerpt

Camelids have unique antibodies, namely HCAbs (VHH) or commercially named Nanobodies(®) (Nb) that are composed only of a heavy-chain homodimer. As libraries based on immunized camelids are time-consuming, costly and likely redundant for certain antigens, we describe the construction of a naïve camelid VHHs library from blood serum of non-immunized camelids with affinity in the subnanomolar range and suitable for...

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Identifiers

PMID: 24702893
DOI: 10.1016/j.crvi.2014.02.004

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