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Article

A cDNA Immunization Strategy to Generate Nanobodies against Membrane Proteins in Native Conformation

23 Jan 2018

Abstract excerpt

Nanobodies (Nbs) are soluble, versatile, single-domain binding modules derived from the VHH variable domain of heavy-chain antibodies naturally occurring in camelids. Nbs hold huge promise as novel therapeutic biologics. Membrane proteins are among the most interesting targets for therapeutic Nbs because they are accessible to systemically injected biologics. In order to be effective, therapeutic Nbs must...

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PMID: 29410663
DOI: 10.3389/fimmu.2017.01989

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