Article
Proteolysis at a specific extracellular residue implicates integral membrane CLAG3 in malaria parasite nutrient channels.
PloS one - 1 Jan 2014
Nguitragool Wang, Rayavara Kempaiah, Desai Sanjay A
Abstract excerpt
The plasmodial surface anion channel mediates uptake of nutrients and other solutes into erythrocytes infected with malaria parasites. The clag3 genes of P. falciparum determine this channel's activity in human malaria, but how the encoded proteins contribute to transport is unknown. Here, we used proteases to examine the channel's composition and function. While proteases with distinct specificities all cleaved...
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