Article
A CLAG3 mutation in an amphipathic transmembrane domain alters malaria parasite nutrient channels and confers leupeptin resistance.
Infection and immunity - 1 Jun 2015
Sharma Paresh, Rayavara Kempaiah, Ito Daisuke, Basore Katherine, Desai Sanjay A
Abstract excerpt
Erythrocytes infected with malaria parasites have increased permeability to ions and nutrients, as mediated by the plasmodial surface anion channel (PSAC) and recently linked to parasite clag3 genes. Although the encoded protein is integral to the host membrane, its precise contribution to solute transport remains unclear because it lacks conventional transmembrane domains and does not have homology to ion...
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