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Article

Proteolytic activation of the essential parasitophorous vacuole cysteine protease SERA6 accompanies malaria parasite egress from its host erythrocyte.

The Journal of biological chemistry - 2 Nov 2012

Ruecker Andrea, Shea Michael, Hackett Fiona, Suarez Catherine, Hirst Elizabeth M A, Milutinovic Katarina, Withers-Martinez Chrislaine, Blackman Michael J

Abstract excerpt

The malaria parasite replicates within an intraerythrocytic parasitophorous vacuole (PV). The PV and host cell membranes eventually rupture, releasing merozoites in a process called egress. Certain inhibitors of serine and cysteine proteases block egress, indicating a crucial role for proteases. The Plasmodium falciparum genome encodes nine serine-repeat antigens (SERAs), each of which contains a central domain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22984267
DOI: 10.1074/jbc.M112.400820
PMCID: PMC3488066

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