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Article

Complex nutrient channel phenotypes despite Mendelian inheritance in a Plasmodium falciparum genetic cross.

PLoS pathogens - 1 Feb 2020

Gupta Ankit, Bokhari Abdullah A B, Pillai Ajay D, Crater Anna K, Gezelle Jeanine, Saggu Gagandeep, Nasamu Armiyaw S, Ganesan Suresh M, Niles Jacquin C, Desai Sanjay A

Abstract excerpt

Malaria parasites activate a broad-selectivity ion channel on their host erythrocyte membrane to obtain essential nutrients from the bloodstream. This conserved channel, known as the plasmodial surface anion channel (PSAC), has been linked to parasite clag3 genes in P. falciparum, but epigenetic switching between the two copies of this gene hinders clear understanding of how the encoded protein determines PSAC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32069335
DOI: 10.1371/journal.ppat.1008363
PMCID: PMC7048409

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