Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rgcs1, a dominant QTL that affects retinal ganglion cell death after optic nerve crush in mice.

BMC neuroscience - 31 Jul 2008

Dietz Joel A, Li Yan, Chung Lisa M, Yandell Brian S, Schlamp Cassandra L, Nickells Robert W

Abstract excerpt

BACKGROUND: Intrinsic apoptosis of neuronal somas is one aspect of neurodegenerative diseases that can be influenced by genetic background. Genes that affect this process may act as susceptibility alleles that contribute to the complex genetic nature of these diseases. Retinal ganglion cell death is a defining feature of the chronic and genetically complex neurodegenerative disease glaucoma. Previous studies...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Vesicular Transport
Share to Calcium-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Death

Share to Extracellular Matrix Proteins

Share to Glaucoma

Share to Mice, Inbred DBA

Share to Retinal Degeneration

Share to Retinal Ganglion Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 18671875
DOI: 10.1186/1471-2202-9-74
PMCID: PMC2518923

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rgcs1, a dominant QTL that affects retinal ganglion cell death after optic nerve crush in mice.PMID 18671875Read ↗

Spink2 modulates apoptotic susceptibility and is a candidate gene in the Rgcs1 QTL that affects retinal ganglion cell death after optic nerve damage.Semantic proximity Read ↗

Dominant inheritance of retinal ganglion cell resistance to optic nerve crush in mice.Semantic proximity Read ↗

Differential response of C57BL/6J mouse and DBA/2J mouse to optic nerve crush.Semantic proximity Read ↗

Commonalities of optic nerve injury and glaucoma-induced neurodegeneration: Insights from transcriptome-wide studiesSemantic proximity Read ↗

Ganglion cell death in glaucoma: from mice to menSemantic proximity Read ↗

Systems Genetics of Optic Nerve Axon Necrosis During GlaucomaSemantic proximity Read ↗

Zebrafish optic nerve injury results in systemic retinal ganglion cell dedifferentiationSemantic proximity Read ↗

DDIT3 (CHOP) contributes to retinal ganglion cell somal loss but not axonal degeneration in DBA/2J miceSemantic proximity Read ↗

Differential Susceptibility of Rat Retinal Ganglion Cells Following Optic Nerve CrushSemantic proximity Read ↗

COMPLEX GENETICS OF GLAUCOMA SUSCEPTIBILITYSemantic proximity Read ↗

The Susceptibility of Retinal Ganglion Cells to Optic Nerve Injury is Type SpecificSemantic proximity Read ↗

Systems Genetics Analysis to Identify the Genetic Modulation of a Glaucoma-Associated Gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.