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Article

Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice.

Neuron - 2 Apr 2014

Sun Suya, Zhang Hua, Liu Jie, Popugaeva Elena, Xu Nan-Jie, Feske Stefan, White Charles L, Bezprozvanny Ilya

Abstract excerpt

Mushroom dendritic spine structures are essential for memory storage, and the loss of mushroom spines may explain memory defects in Alzheimer's disease (AD). Here we show a significant reduction in the fraction of mushroom spines in hippocampal neurons from the presenilin-1 M146V knockin (KI) mouse model of familial AD (FAD). The stabilization of mushroom spines depends on STIM2-mediated neuronal store-operated...

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Source

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Identifiers

PMID: 24698269
DOI: 10.1016/j.neuron.2014.02.019
PMCID: PMC4007018

Genes

STIM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice.PMID 24698269Read ↗

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