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Article

GCK gene-body hypomethylation is associated with the risk of coronary heart disease.

BioMed research international - 1 Jan 2014

Xu Limin, Zheng Dawei, Wang Lingyan, Jiang Danjie, Liu Haibo, Xu Leiting, Liao Qi, Zhang Lina, Liu Panpan, Shi Xinbao, Wang Zhaoyang, Sun Lebo, Zhou Qingyun, Li Ni, Huang Yi, Le Yanping, Ye Meng, Shao Guofeng, Duan Shiwei

Abstract excerpt

OBJECTIVES: Glucokinase encoded by GCK is a key enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Variants of GCK gene were shown to be associated with type 2 diabetes (T2D) and coronary heart disease (CHD). The goal of this study was to investigate the contribution of GCK gene-body methylation to the risk of CHD. DESIGN AND METHODS: 36 patients (18 males and 18 females) and 36 age- and...

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Identifiers

PMID: 24696842
DOI: 10.1155/2014/151723
PMCID: PMC3947703

Genes

GCK

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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