Article
Hypermethylation of hepatic Gck promoter in ageing rats contributes to diabetogenic potential.
Diabetologia - 1 Aug 2008
Jiang M H, Fei J, Lan M S, Lu Z P, Liu M, Fan W W, Gao X, Lu D R
Abstract excerpt
AIMS/HYPOTHESIS: Hepatic glucokinase (GCK) is a key enzyme in glucose utilisation. Downregulation of its activity is associated with insulin resistance and type 2 diabetes mellitus. However, it is unknown whether hepatic Gck expression is influenced by age and is involved in ageing-mediated diabetes, and whether the degree of methylation of the hepatic Gck promoter is correlated with the transcription of Gck. To...
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