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The HSP70 Modulator MAL3-101 Inhibits Merkel Cell Carcinoma

2 Apr 2014

Abstract excerpt

Merkel Cell Carcinoma (MCC) is a rare and highly aggressive neuroendocrine skin cancer for which no effective treatment is available. MCC represents a human cancer with the best experimental evidence for a causal role of a polyoma virus. Large T antigens (LTA) encoded by polyoma viruses are oncoproteins, which are thought to require support of cellular heat shock protein 70 (HSP70) to exert their transforming...

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PMID: 24694787
DOI: 10.1371/journal.pone.0092041

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