Article
Expression, purification and characterization of soluble red rooster laforin as a fusion protein in Escherichia coli.
BMC biochemistry - 2 Apr 2014
Brewer M Kathryn, Husodo Satrio, Dukhande Vikas V, Johnson Mary Beth, Gentry Matthew S
Abstract excerpt
BACKGROUND: The gene that encodes laforin, a dual-specificity phosphatase with a carbohydrate-binding module, is mutated in Lafora disease (LD). LD is an autosomal recessive, fatal progressive myoclonus epilepsy characterized by the intracellular buildup of insoluble, hyperphosphorylated glycogen-like particles, called Lafora bodies. Laforin dephosphorylates glycogen and other glucans in vitro, but the structural...
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