Article

Generation and characterization of a laforin nanobody inhibitor

2021-01-20

Abstract excerpt

Mutations in the gene encoding the glycogen phosphatase laforin result in the fatal childhood epilepsy Lafora disease (LD). A cellular hallmark of LD is cytoplasmic, hyper-phosphorylated, glycogen-like aggregates called Lafora bodies (LBs) that form in nearly all tissues and drive disease progression. Additional tools are needed to define the cellular function of laforin, understand the pathological role of lafori...

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Literature Corpus work: 54c30c18-e1a0-5155-af17-9eeeb0d60da8
DOI: 10.1101/2021.01.20.426524

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