Article
The carbohydrate-binding domain of Lafora disease protein targets Lafora polyglucosan bodies.
Biochemical and biophysical research communications - 23 Jan 2004
Ganesh Subramaniam, Tsurutani Naomi, Suzuki Toshimitsu, Hoshii Yoshinobu, Ishihara Tokuhiro, Delgado-Escueta Antonio V, Yamakawa Kazuhiro
Abstract excerpt
Lafora's disease (LD) is an autosomal recessive and fatal form of epilepsy with onset in late childhood or adolescence. One of the characteristic features of LD pathology is the presence of periodic acid-Schiff (PAS) positive Lafora inclusion bodies. Lafora bodies are present primarily in neurons, but they have also been found in other organs. Histochemical and biochemical studies have indicated that Lafora...
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