Article
Association study of clock gene (CLOCK) and schizophrenia and mood disorders in the Japanese population.
European archives of psychiatry and clinical neuroscience - 1 Aug 2009
Kishi Taro, Kitajima Tsuyoshi, Ikeda Masashi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Okochi Tomo, Okumura Takenori, Tsunoka Tomoko, Inada Toshiya, Ozaki Norio, Iwata Nakao
Abstract excerpt
Recently the clock genes have been reported to play some roles in neural transmitter systems, including the dopamine system, as well as to regulate circadian rhythms. Abnormalities in both of these mechanisms are thought to be involved in the pathophysiology of major mental illness such as schizophrenia and mood disorders including bipolar disorder (BP) and major depressive disorder (MDD). Recent genetic studies...
Topics
- Adult
- Asian People
- Bipolar Disorder
- CLOCK Proteins
- Circadian Rhythm
- Depressive Disorder, Major
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Japan
- Male