Article
Associations of VEGF and VEGFR2 polymorphisms with increased risk and aggressiveness of multiple myeloma.
Annals of hematology - 1 Aug 2014
Brito Angelo Borsarelli Carvalho, Lourenço Gustavo Jacob, Oliveira Gislaine Borba, De Souza Cármino Antônio, Vassallo José, Lima Carmen Silvia Passos
Abstract excerpt
Angiogenesis has been highlighted as a critical component in the progression of multiple myeloma (MM), and vascular endothelial growth factor (VEGF) as well as its type 2 receptor (VEGFR2) are thought to play a major role in the process. Single nucleotide polymorphisms (SNPs) have been described in VEGF and VEGFR2 genes, with quantitative or qualitative changes in encoded VEGF and VEGFR2. The roles of VEGF...
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