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Prophylactic thyroidectomy for asymptomatic 3-year-old boy with positive multiple endocrine neoplasia type 2A mutation (codon 634).

Srpski arhiv za celokupno lekarstvo - 1 Jan 2000

Jesić Maja D, Tancić-Gajić Milina, Jesić Milos M, Zivaljević Vladan, Sajić Silvija, Vujović Svetlana, Damjanović Svetozar

Abstract excerpt

INTRODUCTION: The multiple endocrine neoplasia type 2A (MEN 2A) syndrome, comprising medullary thyroid carcinoma (MTC), pheochromocytoma and primary hyperparathyroidism (PHPT) is most frequently caused by codon 634 activating mutations of the RET (rearranged during transfection) proto-oncogene on chromosome 10. For this codon-mutation carriers, earlier thyroidectomy (before the age of 5 years) would be...

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Identifiers

PMID: 24684035
DOI: 10.2298/sarh1402072j

Genes

RET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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