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Article

Update on the MEN 2A c804 RET mutation: is prophylactic thyroidectomy indicated?

Surgery - 1 Dec 2000

Frohnauer M K, Decker R A

Abstract excerpt

BACKGROUND: Mutations of the RET proto-oncogene co-segregate with multiple endocrine neoplasia type 2A. A rare sequence abnormality at codon 804 (c804) has been reported in 6 kindreds and linked to mild C-cell disease, which raises the question of the appropriateness of thyroidectomy in childhood. The purpose of this study was to (1) report the clinical correlates of 5 additional c804 kindreds, and (2) clarify...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11114642
DOI: 10.1067/msy.2000.11/6/111080

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Update on the MEN 2A c804 RET mutation: is prophylactic thyroidectomy indicated?PMID 11114642Read ↗

Experience of prophylactic thyroidectomy in multiple endocrine neoplasia type 2A kindreds with RET codon 804 mutations.Semantic proximity Read ↗

Long-term outcome in 46 gene carriers of hereditary medullary thyroid carcinoma after prophylactic thyroidectomy: impact of individual RET genotype.Semantic proximity Read ↗

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When is prophylactic thyroidectomy indicated for patients with the RET codon 609 mutation?Semantic proximity Read ↗

Prophylactic thyroidectomy in MEN 2A syndrome: experience in a single center.Semantic proximity Read ↗

The RET mutation E768D confers a late-onset familial medullary thyroid carcinoma -- only phenotype with incomplete penetrance: implications for screening and management of carrier status.Semantic proximity Read ↗

RET proto-oncogene: a review and update of genotype-phenotype correlations in hereditary medullary thyroid cancer and associated endocrine tumors.Semantic proximity Read ↗

RET germline mutation in codon 791 in a family representing 3 generations from age 5 to age 70 years: should thyroidectomy be performed?Semantic proximity Read ↗

Variable expressivity of familial medullary thyroid carcinoma (FMTC) due to a RET V804M (GTG-->ATG) mutation.Semantic proximity Read ↗

2012 European Thyroid Association Guidelines for Genetic Testing and Its Clinical Consequences in Medullary Thyroid CancerSemantic proximity Read ↗

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