Article
Synthesis and biological evaluation of arabinose 5-phosphate mimics modified at position five.
Carbohydrate research - 7 May 2014
Cipolla Laura, Airoldi Cristina, Sperandeo Paola, Gianera Serena, Polissi Alessandra, Nicotra Francesco, Gabrielli Luca
Abstract excerpt
A set of new metabolically stable arabinose 5-phosphate analogues possessing phosphate mimetic groups at position 5 was synthesised. Their ability to interact with arabinose 5-phosphate isomerase from Pseudomonas aeruginosa was evaluated by STD-NMR studies. The synthesised compounds were also characterised for their activity in vivo on P. aeruginosa and Escherichia coli strains. Unfortunately, none of the...
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