Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Opposing effects of HIF1α and HIF2α on chromaffin cell phenotypic features and tumor cell proliferation: Insights from MYC-associated factor X.

International journal of cancer - 1 Nov 2014

Qin Nan, de Cubas Aguirre A, Garcia-Martin Ruben, Richter Susan, Peitzsch Mirko, Menschikowski Mario, Lenders Jacques W M, Timmers Henri J L M, Mannelli Massimo, Opocher Giuseppe, Economopoulou Matina, Siegert Gabriele, Chavakis Triantafyllos, Pacak Karel, Robledo Mercedes, Eisenhofer Graeme

Abstract excerpt

Pheochromocytomas and paragangliomas (PPGLs) are catecholamine-producing chromaffin cell tumors with diverse phenotypic features reflecting mutations in numerous genes, including MYC-associated factor X (MAX). To explore whether phenotypic differences among PPGLs reflect a MAX-mediated mechanism...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenal Gland Neoplasms
Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Basic Helix-Loop-Helix Transcription Factors

Share to Chromaffin Cells

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Paraganglioma

Share to Pheochromocytoma

Share to Real-Time Polymerase Chain Reaction

Source

Identifiers

PMID: 24676840
DOI: 10.1002/ijc.28868

Genes

MAX
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24676840-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Opposing effects of HIF1α and HIF2α on chromaffin cell phenotypic features and tumor cell proliferation: Insights from MYC-associated factor X.PMID 24676840Read ↗

Role of hypoxia and HIF2α in development of the sympathoadrenal cell lineage and chromaffin cell tumors with distinct catecholamine phenotypic features.Semantic proximity Read ↗

Hypoxia-inducible Factor 2α: A Key Player in Tumorigenesis and Metastasis of Pheochromocytoma and Paraganglioma?Semantic proximity Read ↗

Hypoxia-inducible factor signaling in pheochromocytoma: turning the rudder in the right direction.Semantic proximity Read ↗

A new twist in neuroendocrine tumor research: Pacak-Zhuang syndrome, HIF-2α as the major player in its pathogenesis and future therapeutic options.Semantic proximity Read ↗

Patient-derived organoids reveal hypoxia-driven plasticity and therapeutic vulnerabilities in pheochromocytomas and paragangliomasSemantic proximity Read ↗

From transcriptional profiling to tumor biology in pheochromocytoma and paraganglioma.Semantic proximity Read ↗

HIF2α supports pro-metastatic behavior in pheochromocytomas/paragangliomasSemantic proximity Read ↗

HIF2α negatively regulates MYCN protein levels and promotes a low-risk noradrenergic phenotype in neuroblastomaSemantic proximity Read ↗

HIF Signaling Pathway in Pheochromocytoma and Other Neuroendocrine TumorsSemantic proximity Read ↗

The VHL/HIF Axis in the Development and Treatment of Pheochromocytoma/ParagangliomaSemantic proximity Read ↗

Hypoxia-Inducible Factor 2α Mutation-Related Paragangliomas Classify as Discrete Pseudohypoxic Subcluster.Semantic proximity Read ↗

In vivo and in vitro oncogenic effects of HIF2A mutations in pheochromocytomas and paragangliomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.