Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypoxia-inducible factor signaling in pheochromocytoma: turning the rudder in the right direction.

Journal of the National Cancer Institute - 4 Sept 2013

Jochmanová Ivana, Yang Chunzhang, Zhuang Zhengping, Pacak Karel

Abstract excerpt

Many solid tumors, including pheochromocytoma (PHEO) and paraganglioma (PGL), are characterized by a (pseudo)hypoxic signature. (Pseudo)hypoxia has been shown to promote both tumor progression and resistance to therapy. The major mediators of the transcriptional hypoxic response are hypoxia-inducible factors (HIFs). High levels of HIFs lead to transcription of hypoxia-responsive genes, which are involved in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenal Gland Neoplasms
Share to Cell Hypoxia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia-Inducible Factor 1

Share to Multiple Endocrine Neoplasia Type 2a

Share to Neurofibromatosis 1

Share to Paraganglioma

Share to Pheochromocytoma

Share to von Hippel-Lindau Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 23940289
DOI: 10.1093/jnci/djt201
PMCID: PMC3888279

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypoxia-inducible factor signaling in pheochromocytoma: turning the rudder in the right direction.PMID 23940289Read ↗

HIF Signaling Pathway in Pheochromocytoma and Other Neuroendocrine TumorsSemantic proximity Read ↗

The VHL/HIF Axis in the Development and Treatment of Pheochromocytoma/ParagangliomaSemantic proximity Read ↗

A new twist in neuroendocrine tumor research: Pacak-Zhuang syndrome, HIF-2α as the major player in its pathogenesis and future therapeutic options.Semantic proximity Read ↗

Hypoxia Pathway Mutations in Pheochromocytomas and Paragangliomas.Semantic proximity Read ↗

Genetics of pheochromocytoma and paraganglioma syndromes: new advances and future treatment options.Semantic proximity Read ↗

New insights on the pathogenesis of paraganglioma and pheochromocytomaSemantic proximity Read ↗

Hypoxia-Inducible Factor 2α Mutation-Related Paragangliomas Classify as Discrete Pseudohypoxic Subcluster.Semantic proximity Read ↗

Role of hypoxia and HIF2α in development of the sympathoadrenal cell lineage and chromaffin cell tumors with distinct catecholamine phenotypic features.Semantic proximity Read ↗

Genomic Landscape of Pheochromocytoma and Paraganglioma.Semantic proximity Read ↗

Hypoxia-inducible Factor 2α: A Key Player in Tumorigenesis and Metastasis of Pheochromocytoma and Paraganglioma?Semantic proximity Read ↗

The connection between tricarboxylic acid cycle enzyme mutations and pseudohypoxic signaling in pheochromocytoma and paraganglioma.Semantic proximity Read ↗

An update on the genetics of paraganglioma, pheochromocytoma, and associated hereditary syndromes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.