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HIF2α supports pro-metastatic behavior in pheochromocytomas/paragangliomas

14 Sept 2020

Abstract excerpt

Mutations that drive the stabilization of hypoxia inducible factor 2α (HIF2α) and downstream pseudohypoxic signaling are known to predispose to the development of pheochromocytomas and paragangliomas (PPGLs). However, any role of HIF2α in predisposition to metastatic disease remains unclear. To assess such a role we combined gene-manipulations in pheochromocytoma cell lines with retrospective analyses of patient...

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PMID: 33112842
DOI: 10.1530/erc-20-0205

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