A dose and time response Markov model for the in-host dynamics of infection with intracellular bacteria following inhalation: with application toFrancisella tularensis

Abstract excerpt

In a novel approach, the standard birth-death process is extended to incorporate a fundamental mechanism undergone by intracellular bacteria, phagocytosis. The model accounts for stochastic interaction between bacteria and cells of the immune system and heterogeneity in susceptibility to infection of individual hosts within a population. Model output is the dose-response relation and the dose-dependent...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bacillus and Francisella bacterial research
• Share to Inhalation and Respiratory Drug Delivery
• Share to Yersinia bacterium, plague, ectoparasites research