Platelet serotonin transporter function predicts default-mode network activity.

doi:10.1371/journal.pone.0092543

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Article

Platelet serotonin transporter function predicts default-mode network activity.

PloS one - 1 Jan 2014

Scharinger Christian, Rabl Ulrich, Kasess Christian H, Meyer Bernhard M, Hofmaier Tina, Diers Kersten, Bartova Lucie, Pail Gerald, Huf Wolfgang, Uzelac Zeljko, Hartinger Beate, Kalcher Klaudius, Perkmann Thomas, Haslacher Helmuth, Meyer-Lindenberg Andreas, Kasper Siegfried, Freissmuth Michael, Windischberger Christian, Willeit Matthäus, Lanzenberger Rupert, Esterbauer Harald, Brocke Burkhard, Moser Ewald, Sitte Harald H, Pezawas Lukas

Abstract excerpt

BACKGROUND: The serotonin transporter (5-HTT) is abundantly expressed in humans by the serotonin transporter gene SLC6A4 and removes serotonin (5-HT) from extracellular space. A blood-brain relationship between platelet and synaptosomal 5-HT reuptake has been suggested, but it is unknown today, if platelet 5-HT uptake can predict neural activation of human brain networks that are known to be under serotonergic...

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PMID: 24667541
DOI: 10.1371/journal.pone.0092543
PMCID: PMC3965432

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