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Article

Effects of Serotonin Transporter Gene Variation on Impulsivity Mediated by Default Mode Network: A Family Study of Depression.

Cerebral cortex (New York, N.Y. : 1991) - 1 Jun 2018

Cha Jiook, Guffanti Guia, Gingrich Jay, Talati Ardesheer, Wickramaratne Priya, Weissman Myrna, Posner Jonathan

Abstract excerpt

Serotonergic neurotransmission, potentially through effects on the brain's default mode network (DMN), may regulate aspects of attention including impulse control. Indeed, genetic variants of the serotonin transporter (5-HTT) have been implicated in impulsivity and related psychopathology. Yet it remains unclear the mechanism by which the 5-HTT genetic variants contribute to individual variability in impulse...

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Identifiers

PMID: 28444137
DOI: 10.1093/cercor/bhx097
PMCID: PMC6019008

Genes

HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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