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Article

Flipping the Switch: Integrin Switching Provides Metastatic Competence

25 Mar 2014

Abstract excerpt

Integrin switching plays a critical role in the progression to metastatic disease, but the mechanism by which it contributes remains poorly understood. In the 11 February 2014 issue of Science Signaling, Truong et al. identified a transforming growth factor-β-mediated, prometastatic switch that is activated by β1 integrin inhibition in triple-negative breast cancers (TNBCs). Their work provides insight into the...

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PMID: 24667375
DOI: 10.1126/scisignal.2005236

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