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Article

Prospective study of high-risk, BRCA1/2-mutation negative women: the 'negative study'.

BMC cancer - 25 Mar 2014

Kotsopoulos Joanne, Metcalfe Kelly, Alston Jill, Nikitina Dina, Ginsburg Ophira, Eisen Andrea, Demsky Rochelle, Akbari Mohammad, Zbuk Kevin, Narod Steven A

Abstract excerpt

BACKGROUND: We previously reported that women from high-risk families who tested negative for a BRCA1 or BRCA2 (BRCA1/2) mutation were four times more likely to develop breast cancer compared to women in the general population. Preventive measures and risk factors for breast cancer development in these high-risk women have not been evaluated to the same extent as BRCA1/2 positive women. Further, there is...

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Identifiers

PMID: 24667084
DOI: 10.1186/1471-2407-14-221
PMCID: PMC3973748

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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