Article
Impact of hexavalent chromium on mammalian cell bioenergetics: phenotypic changes, molecular basis and potential relevance to chromate-induced lung cancer.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine - 1 Jun 2014
Abreu P L, Ferreira L M R, Alpoim M C, Urbano A M
Abstract excerpt
Occupational exposure to hexavalent chromium [Cr(VI)] has been firmly associated with the development of several pathologies, notably lung cancer. According to the current paradigm, the evolution of normal cells to a neoplastic state is accompanied by extensive metabolic reprogramming, namely at the level of energy-transducing processes. Thus, a complete understanding of the molecular basis of Cr(VI)-induced lung...
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