Article
Exosomal HIF1α supports invasive potential of nasopharyngeal carcinoma-associated LMP1-positive exosomes.
Oncogene - 11 Sept 2014
Aga M, Bentz G L, Raffa S, Torrisi M R, Kondo S, Wakisaka N, Yoshizaki T, Pagano J S, Shackelford J
Abstract excerpt
It has emerged recently that exosomes are potential carriers of pro-tumorigenic factors that participate in oncogenesis. However, whether oncogenic transcription factors are transduced by exosomes is unknown. Hypoxia-inducible factor-1α (HIF1α) transcriptionally regulates numerous key aspects of tumor development and progression by promoting a more aggressive tumor phenotype, characterized by increased...
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