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Article

STIM1-regulated exosomal EBV-LMP1 empowers endothelial cells with an aggressive phenotype by activating the Akt/ERK pathway in nasopharyngeal carcinoma.

Cellular oncology (Dordrecht, Netherlands) - 1 Aug 2023

Deng Yayan, Liu Xue, Huang Yujuan, Ye Jiaxiang, He Qian, Luo Yue, Chen Yong, Li Qiuyun, Lin Yan, Liang Rong, Li Yongqiang, Wei Jiazhang, Zhang Jinyan

Abstract excerpt

BACKGROUND: Stromal interaction molecule 1 (STIM1)-mediated Ca2+ signaling regulates tumor angiogenesis in nasopharyngeal carcinoma (NPC), an Epstein-Barr virus (EBV)-related human malignancy. However, the mechanism by which STIM1 modulates endothelial functional phenotypes contributing to tumor angiogenesis remains elusive. METHODS: NPC cell-derived exosomes were isolated via differential centrifugation and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36917356
DOI: 10.1007/s13402-023-00790-0
PMCID: PMC12974713

Genes

STIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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