Article
miR-29 and miR-30 regulate B-Myb expression during cellular senescence.
Proceedings of the National Academy of Sciences of the United States of America - 11 Jan 2011
Martinez Ivan, Cazalla Demian, Almstead Laura L, Steitz Joan A, DiMaio Daniel
Abstract excerpt
Cellular senescence is a form of irreversible growth arrest and a major tumor suppressor mechanism. We show here that the miR-29 and miR-30 microRNA families are up-regulated during induced and replicative senescence and that up-regulation requires activation of the Rb pathway. Expression of a reporter construct containing the 3'UTR of the B-Myb oncogene is repressed during senescence, and repression is blocked...
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