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Article

MicroRNA-146a and Ets-1 gene polymorphisms are associated with pediatric uveitis.

PloS one - 1 Jan 2014

Wei Lin, Zhou Qingyun, Hou Shengping, Bai Lin, Liu Yunjia, Qi Jian, Xiang Qin, Zhou Yan, Kijlstra Aize, Yang Peizeng

Abstract excerpt

BACKGROUND: MicroRNA-146a (miR-146a) was a key negative regulator of autoimmunity. V-Ets oncogene homolog 1 (Ets-1) was demonstrated to bind to the miR-146a promoter region and markedly affects miR-146a promoter activity. This study aimed to investigate the association of miR-146a and Ets-1 gene polymorphisms with pediatric uveitis in a Han Chinese population. METHODOLOGY/PRINCIPAL FINDINGS: A total of 520...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24658012
DOI: 10.1371/journal.pone.0091199
PMCID: PMC3962359

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