Article
MiR-146a polymorphism is associated with asthma but not with systemic lupus erythematosus and juvenile rheumatoid arthritis in Mexican patients.
Tissue antigens - 1 Oct 2012
Jiménez-Morales S, Gamboa-Becerra R, Baca V, Del Río-Navarro B E, López-Ley D Y, Velázquez-Cruz R, Saldaña-Alvarez Y, Salas-Martínez G, Orozco L
Abstract excerpt
Extensive research has shown that aberrant expression of microRNAs (miRNAs) plays an important role in innate and adaptive immune responses. The rs2910164 polymorphism has been identified as a functional variant, which affects the transcription and expression level of miR-146a and, thereby, contributes to the pathogenesis of several inflammatory and autoimmune diseases. To investigate whether the rs2910164 G/C...
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