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Article

Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells.

European journal of pharmacology - 5 Jun 2014

Summers Carolyn M, Hammons Andrea L, Arora Jasbir, Zhang Suhong, Jochems Jeanine, Blair Ian A, Whitehead Alexander S

Abstract excerpt

EA.hy 926 cells grown under low folate conditions adopt a "pro-atherosclerotic" morphology and biochemical phenotype. Pharmacologically relevant doses of the antifolate drug methotrexate (MTX) were applied to EA.hy 926 cells maintained in normal (Hi) and low (Lo) folate culture media. Under both folate conditions, MTX caused inhibition of cell proliferation without significantly compromising metabolic activity....

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Identifiers

PMID: 24657277
DOI: 10.1016/j.ejphar.2014.03.004
PMCID: PMC4402228

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