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Article

Pemetrexed alters folate phenotype and inflammatory profile in EA.hy 926 cells grown under low-folate conditions.

European journal of pharmacology - 5 Dec 2012

Hammons Andrea L, Summers Carolyn M, Jochems Jeanine, Arora Jasbir S, Zhang Suhong, Blair Ian A, Whitehead Alexander S

Abstract excerpt

Elevated homocysteine is a risk marker for several major human pathologies. Emerging evidence suggests that perturbations of folate/homocysteine metabolism can directly modify production of inflammatory mediators. Pemetrexed acts by inhibiting thymidylate synthetase (TYMS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). EA.hy 926 cells grown under low ("Lo") and high...

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Identifiers

PMID: 22975265
DOI: 10.1016/j.ejphar.2012.08.008
PMCID: PMC4051202

Genes

DHFR
TYMS

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