Article
Reduced variability of tacrolimus trough level in once-daily tacrolimus-based Taiwanese kidney transplant recipients with high-expressive genotype of cytochrome P450 3A5.
Transplantation proceedings - 1 Jan 2014
Wu M-J, Chang C-H, Cheng C-Y, Shu K-H, Chen C-H, Cheng C-H, Yu T-M, Chuang Y-W, Huang S-T, Tsai S-F, Ho H-C, Li J-R, Shiu Y-N, Fu Y-C
Abstract excerpt
BACKGROUND: Our previous study results indicated that conversion from twice-daily Prograf to once-daily Advagraf associated with lower variability of tacrolimus blood trough level. Some factors, such as frequency of interaction by food exposure, expression of cytochrome P450 3A5 genetic polymorphism, and other interactions of unknown factors, could be the reasons for the change of variability. We aimed to clarify...
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