Article
Reduced variability of tacrolimus trough level in once-daily tacrolimus-based Taiwanese kidney transplant recipients with high-expressive genotype of cytochrome P450 3A5.
Transplantation proceedings - 1 Jan 2014
Wu M-J, Chang C-H, Cheng C-Y, Shu K-H, Chen C-H, Cheng C-H, Yu T-M, Chuang Y-W, Huang S-T, Tsai S-F, Ho H-C, Li J-R, Shiu Y-N, Fu Y-C
Abstract excerpt
BACKGROUND: Our previous study results indicated that conversion from twice-daily Prograf to once-daily Advagraf associated with lower variability of tacrolimus blood trough level. Some factors, such as frequency of interaction by food exposure, expression of cytochrome P450 3A5 genetic polymorph...
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