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The expression of four pyridoxal kinase (PDXK) human variants in Drosophila impacts on genome integrity

2 Oct 2019

Abstract excerpt

Abstract In eukaryotes, pyridoxal kinase (PDXK) acts in vitamin B6salvage pathway to produce pyridoxal 5′-phosphate (PLP), the active form of the vitamin, which is implicated in numerous crucial metabolic reactions. In Drosophila, mutations in the dPdxk gene cause chromosome aberrations (CABs) and increase glucose content in larval hemolymph. Both phenotypes are rescued by the expression of the wild type human...

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PMID: 31578392
DOI: 10.1038/s41598-019-50673-4

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