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Article

Transcript analysis reveals a specific HOX signature associated with positional identity of human endothelial cells.

PloS one - 1 Jan 2014

Toshner Mark, Dunmore Benjamin J, McKinney Eoin F, Southwood Mark, Caruso Paola, Upton Paul D, Waters John P, Ormiston Mark L, Skepper Jeremy N, Nash Gerard, Rana Amer A, Morrell Nicholas W

Abstract excerpt

The endothelial cell has a remarkable ability for sub-specialisation, adapted to the needs of a variety of vascular beds. The role of developmental programming versus the tissue contextual environment for this specialization is not well understood. Here we describe a hierarchy of expression of HOX genes associated with endothelial cell origin and location. In initial microarray studies, differential gene...

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Source

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Identifiers

PMID: 24651450
DOI: 10.1371/journal.pone.0091334
PMCID: PMC3961275

Genes

HOXD8
HOXD9
HOXD1
HOXD3
HOXD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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