Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The methylenetetrahydrofolate reductase gene variant (C677T) as a susceptibility gene for tetralogy of Fallot.

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology - 1 Jan 2000

Marinho Cláudia, Alho Irina, Guerra António, Rego Carla, Areias José, Bicho Manuel

Abstract excerpt

The aim of this study was to evaluate whether the cytosine-to-thymine mutation at base 677 of the methylenetetrahydrofolate reductase gene (MTHFR C677T), which has been associated with neural tube defects and congenital oral cleft, is also associated with tetralogy of Fallot (TF), a congenital heart disease. The MTHFR C677T genotype was investigated in a sample of 38 children born with TF who underwent surgical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Polymorphism, Genetic

Share to Tetralogy of Fallot

Share to Young Adult

Source

Identifiers

PMID: 19894660

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The methylenetetrahydrofolate reductase gene variant (C677T) as a susceptibility gene for tetralogy of Fallot.PMID 19894660Read ↗

MTHFR rs1801133 C>T polymorphism is associated with an increased risk of tetralogy of FallotSemantic proximity Read ↗

Association of the C677T methylenetetrahydrofolate reductase mutation with congenital heart diseases.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase C677T and reduced folate carrier 80 G>A polymorphisms are associated with an increased risk of conotruncal heart defects.Semantic proximity Read ↗

Infant methylenetetrahydrofolate reductase 677TT genotype is a risk factor for congenital heart disease.Semantic proximity Read ↗

5,10 Methylenetetrahydrofolate reductase genetic polymorphism as a risk factor for neural tube defects.Semantic proximity Read ↗

[Methylene tetrahydrofolate reductase mutations as genetic risk factors for neural tube defects (NTF)].Semantic proximity Read ↗

A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects.Semantic proximity Read ↗

Decreased methylene tetrahydrofolate reductase activity due to the 677C-->T mutation in families with spina bifida offspring.Semantic proximity Read ↗

Presence of the 5,10-methylenetetrahydrofolate reductase C677T mutation in Puerto Rican patients with neural tube defects.Semantic proximity Read ↗

VEGF Gene Polymorphisms are Associated with Risk of Tetralogy of Fallot.Semantic proximity Read ↗

Polymorphisms of the 5,10-methylenetetrahydrofolate and the methionine synthase reductase genes as independent risk factors for spina bifida.Semantic proximity Read ↗

Analysis of the MTHFR 1298A-->C and 677C-->T polymorphisms as risk factors for neural tube defects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.