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Article

Interaction between allelic variations in vitamin D receptor and retinoid X receptor genes on metabolic traits.

BMC genetics - 19 Mar 2014

Vimaleswaran Karani S, Cavadino Alana, Berry Diane J, Mangino Massimo, Andrews Peter, Moore Jason H, Spector Timothy D, Power Chris, Järvelin Marjo-Riitta, Hyppönen Elina

Abstract excerpt

BACKGROUND: Low vitamin D status has been shown to be a risk factor for several metabolic traits such as obesity, diabetes and cardiovascular disease. The biological actions of 1, 25-dihydroxyvitamin D, are mediated through the vitamin D receptor (VDR), which heterodimerizes with retinoid X receptor, gamma (RXRG). Hence, we examined the potential interactions between the tagging polymorphisms in the VDR (22 tag...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24641809
DOI: 10.1186/1471-2156-15-37
PMCID: PMC4004151

Genes

RXRG
VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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