Article
A 4.5-Year Within-Patient Evolution of a Colistin-Resistant Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae Sequence Type 258.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Oct 2018
Jousset Agnès B, Bonnin Rémy A, Rosinski-Chupin Isabelle, Girlich Delphine, Cuzon Gaëlle, Cabanel Nicolas, Frech Hélène, Farfour Eric, Dortet Laurent, Glaser Philippe, Naas Thierry
Abstract excerpt
Background: Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-Kp) has emerged globally over the last decade as a major nosocomial pathogen that threatens patient care. These highly resistant bacteria are mostly associated with a single Kp clonal group, CG258, but the reasons for its host and hospital adaptation remain largely unknown. Methods: We analyzed the in vivo evolution of a...
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