Article
Genomic Analysis of the Emergence and Rapid Global Dissemination of the Clonal Group 258 Klebsiella pneumoniae Pandemic.
PloS one - 1 Jan 2015
Bowers Jolene R, Kitchel Brandon, Driebe Elizabeth M, MacCannell Duncan R, Roe Chandler, Lemmer Darrin, de Man Tom, Rasheed J Kamile, Engelthaler David M, Keim Paul, Limbago Brandi M
Abstract excerpt
Multidrug-resistant Klebsiella pneumoniae producing the KPC carbapenemase have rapidly spread throughout the world, causing severe healthcare-associated infections with limited antimicrobial treatment options. Dissemination of KPC-producing K. pneumoniae is largely attributed to expansion of a single dominant strain, ST258. In this study, we explore phylogenetic relationships and evolution within ST258 and its...
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